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In July 2017, the Food and Drug Administration announced a major shift in its tobacco strategy, including recognizing the role of less harmful products, such as e-cigarettes, for smokers who want a satisfying alternative to smoking cigarettes

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MMPs degrade extracellular matrix proteins such as collagens, elastin and glycoprotein, which in this context include bone extracellular matrix proteins such as type I collagen [49]

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Pulm Med 2016:4894352 Jha P, Ramasundarahettige C, Landsman V, Rostron B, Thun M, Anderson RN et al (2013) 21st-century hazards of smoking and benefits of cessation in the United States