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Across these hubs of Illicit trade especially in Free Trade Zones (FTZs) the illegal tobacco trade continues to expand a global ecosystem of criminality, and to spur increased violence, corruption, and dangerous entanglements as criminals and other threat networks fight over illicit pathways to move illegal goods and other contraband resulting in a convergence of transnational threats that has evolved to become more complex, volatile, and destabilizing

Theres less throat irritation (especially with nicotine salts)

This process of inflammation-induced loss of tight and adherens junctions predisposes the epithelium to further infection and exacerbates the persistent chronic inflammatory state seen in COPD