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Furthermore, the study population was utterly independent of previous GWASs that identified the risk loci and their effect sizes, which avoided overfitting to some extent

The strips, which are designed for sublingual administration, contain buprenorphine (a partial opioid agonist that binds to opioid receptors in the brain) to alleviate withdrawal symptoms and reduce cravings and naloxone (an opioid antagonist) to prevent misuse by blocking opioid effects if tampered with

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