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Adapting to new laws may require expensive modifications to equipment and products

The act of inhaling draws the smoke deeper into the respiratory system, resulting in the rapid absorption of nicotine and other chemicals

Retrieved April 12, 2023

While not risk-free, mainly due to sustained nicotine intake, pouches are a harm reduction alternative for adult smokers unwilling or unable to quit nicotine entirely.

Randomization After the 2-week run-in phase, stage 2 will be initiated, in which participants who fail to achieve 7-day abstinence (self-report of not smoking for at least the past 7 days at week 3 study visit) will be randomly assigned to the experimental (group A, escalating active patches) or a control condition (group B, escalating placebo patches) for 10 additional weeks of treatment