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doi:10.7326/0003-4819-142-4-200502150-00005

Nevertheless, the stems make up a significant part of the tobacco leaf and contain tar, nicotine and other components inherent in tobacco, so in the past significant efforts were made to master this material, which in the 1970s led to the emergence of the cut rolled stem, (CRS)

Authors concluded that combining NRT with behaviour change counselling resulted in a significantly higher quit rates and lower cotinine levels, but significant impact on patient-related or microbiological outcomes were not detected (Sharma et al., 2018)

In the UK, the NHS has identified smoking as the biggest cause of preventable deaths, leading to diseases such as heart disease, stroke, and several types of cancer