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Current recommendations suggest that all interventions be initiated in any patient in whom glucocorticoid therapy with at least the equivalent of 5 mg of prednisone for at least 3 months is anticipated

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Inflammation and the gut-brain connection Cigarette smoke increases low-grade inflammation in the intestines. Since IBS is strongly influenced by the gut-brain axis (the two-way communication between the gut and the nervous system), this extra stress can worsen how signals are processed, leading to more discomfort and unpredictability

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