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However, a paucity of studies investigated the microbes in tobacco recent years, and this may be incriminated as causative factors in smoking-associated diseases

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Palmar telangiectasia, which happens on the palms of the hands, can be caused by smoking due to the nicotine in tobacco which reduces blood vessel size

Northern Tobacco, in its 2017 monitoring of one tobacco-growing region from which it sources in Zimbabwe, confirmed high rates of absenteeism due to farmers difficulty paying school fees and risks of child labor during the most labor-intensive tobacco farming periods