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Prolonged use damages various organs and systems, spawning life-threatening consequences

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While he might have realized the impact his protagonists would have on pop culture, television, and storytelling at large, Carter probably didnt anticipate that a character defined by his chain-smoking habit would become such a lasting figure, too

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This is manifested by increased mitochondrial mass, fusion, and leaky mitochondrial membranes, phenomena that result from an impaired autophagic mechanism that scavenges damaged mitochondria (i.e., mitochondrial autophagy) (85)