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This complexity underlies the dual potential of cannabinoids to provide therapeutic benefit in conditions such as chronic pain and multiple sclerosis while simultaneously contributing to adverse outcomes including cognitive impairment, immune dysregulation, and possibly increased cancer risk

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At the same time, many tobacco companies have diversified into reduced-risk products such as heated tobacco devices and nicotine pouches

11 However, it is important to consider that immune altering effects of E-cig use might be location and macrophage differentiation-dependent

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