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"The whole mission is to decrease harm from smoking, which is not from the nicotine per se, but all the carcinogens and other chemicals that are in tobacco smoke," said Lazarus, senior author on the study published in the journal Chemical Research in Toxicology

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In the U.S., that number is closer to 10%, after decades of steady decline

For sensitivity analysis, three different methods were applied: convergence testing during the probabilistic simulation, application of a factor to consider drug tolerance and comparison with human toxicological thresholds for some of the agents

The majority of older adults use vaping products below 20 mg/mL nicotine and this was the case even prior to the observed increase in youth vaping, as vaping products were mostly available in those concentrations prior to 2018