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The variable numbers of necrotic keratinocytes revealed by histopathology suggest that blister formation may be the result of a phototoxic reaction,7,8 while the near exclusive location of the lesions on the lower limbs suggests that friction and trauma may trigger lesion formation.8 Heidbreder and Henseler5 demonstrated that PUVA treatment inhibits the synthesis of connective tissue and increases collagen fractionation, resulting in a loss of dermoepidermal cohesion

The official publication of the Scientific Research Society, American Scientist , reported that alcohol is one of the most toxic drugs and using just 10 times what one would use to get the desired effect could lead to death

If material is not included in the articles Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.To view a copy of this licence, visit About this article Cite this article Rajakumar, H.K., Coimbatore Sathyabal, V., Jabarulla, K.N

Retrieved February 20, 2026

doi: 10.2105/ajph.89.9.1434