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However, this is a preliminary investigation about the potential associations between substance use and different psychiatric disorders, and a more informative design would have examined multimodal brain networks in (a) alcohol/tobacco use subjects, (b) psychotic subjects with and without alcohol/tobacco use, (c) depressive subjects with and without alcohol/tobacco use and (d) developmental disorders with and without alcohol/tobacco use

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They havent been studied in a rigorous manner. Rizzo also notes that studies on e-cigarettes are especially challenging due to difficulties in making direct comparisons

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