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Clinical studies Acute cardiovascular effects Acute effects of conventional smoking, such as increased blood pressure, heart rate, and vascular resistance, have been known for decades [155,156,157,158,159,160]

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Conclusion Cigarette smoking is associated with integrated activation of inflammatory, oxidative, and platelet pathways, with dose-dependent relationships to exposure, supporting a model in which smoking promotes a prothrombotic and proinflammatory state through multiple converging mechanisms

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