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For those struggling with tobacco addiction, seeking help is an important step

The carcinogenic effect is based on reactive metabolites of nitrosamines in the metabolism, which react with the genetic material DNA, damaging it and triggering tumors

For instance, a meta-analysis of 19 peer-reviewed studies that included a total of 11,590 COVID patients worldwide found that smoking nearly doubled the risk of progression of COVID-19

Thus, the conditional recommendation against using them considers the resource implications and opportunity costs if people who smoke use these interventions instead of behavioural interventions with evidence of effectiveness

Addressing this could really help in making efforts to lower smoking rates and protect folks' mental sharpness along with their physical health