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This model utilizes the least squares method to estimate the patterns of change in disease rates, thereby avoiding the non-objectivity inherent in typical trend analyses based on linear assumptions

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Notably, the novel calcitonin gene-related peptide (CGRP) receptor antagonist rimegepant has demonstrated unique advantages in recent clinical trials, showing efficacy not only in alleviating acute-phase headache symptoms (with a 35% higher 2-h pain freedom rate versus placebo) but also achieving a 62% improvement rate for accompanying vertigo symptoms (72)

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