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Concurrently, we conducted SMR analysis using gene eQTLs data and NSCLC to further ascertain the causal relationship between the intersected genes and NSCLC ( 2.6 Mediation analysis Utilizing the TSMR method, we initially calculated the total effect ( 0 ) of different smoking statuses on NSCLC, the effect ( 1 ) of different smoking statuses on potential therapeutic targets, and the effect ( 2 ) of potential therapeutic targets on NSCLC

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