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ND heritability is enriched for genes expressed in cerebellum To assess whether heritability of ND is enriched in regions surrounding genes with the highest specific expression patterns in given tissue/cell type(s), we applied LDSC-SEG 44 using the EUR-specific ND GWAS meta-analysis results with reference to 205 tissues/cell types with publicly available gene expression data assembled from GTEx 45 (53 human tissues/cell types) and the underlying data that is used to comprise the Data-driven Expression Prioritized Integration for Complex Traits (DEPICT) tool 46,47 (152 tissues/cell types from humans and rodent models)

Additional benefits include: Potentially enhanced effectiveness of diabetes medications , which may allow dose reductions over time Improved immune function and reduced infection rates Better response to physical activity , supporting weight management and fitness Reduced healthcare costs through fewer complications and hospitalisations Improved quality of life , including better energy levels and physical functioning NICE guidelines emphasise that smoking cessation represents one of the most cost-effective interventions in diabetes care, with benefits that extend well beyond glucose control to encompass overall health and longevity

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