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Legal and Regulatory Landscape While the market continues to develop, here's what Italian customers need to know: People can purchase and use nicotine pouches from major brands like ZYN, VELO, and LOOP in Italy You must be at least 18 years old to buy nicotine pouches Current taxation on nicotine pouches ranges from 22 per kilogram as of January 1, 2023 Customs regulations allow for personal imports of reasonable quantities As part of the European Union, Italy follows similar nicotine pouch regulations to neighboring countries like France and Spain

A brief history of tobacco marketing and regulations This type of advertising program is not new to the industry

Dimensions: 3160 x 2000 px | 26.8 x 16.9 cm | 10.5 x 6.7 inches | 300dpi Date taken: 10 November 2022

Cigarette smoke induces phosphorylation, and, thus, activation, of key proteins associated with inflammation (Figure 1)

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