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doi: 10.1056/NEJMsa1211128

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But the unique part of this study is that we found elements in what we call the virgin e-liquid, meaning that the device has never been used. This design is known as a closed system, so youre not changing out the coil, which Poulin says was a common feature of the previous-generation devices, and may help explain why the newer disposable e-cigarettes are more harmful