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Yu et al [75] reported that the histone abnormality rate in a Chinese population was lowest in normozoospermic non-smoking men and highest in heavy smokers with oligospermia

Despite international efforts to reduce tobacco consumption, SLT use remains prevalent

Fibrotic HP is very similar to idiopathic pulmonary fibrosis (IPF) and is probably responsible for recruiting fibrocytes and the activation of fibroblasts, and therefore, the uncontrolled deposition of ECM-related proteins [186]

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Combining with existing observational evidence, we provided novel insights regarding a positive feedback loop of smoking through Actinobacteria and indicated a potential mechanism for the link between parental smoking and early smoking initiation of their children driven by Bifidobacterium