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Release of hydrogen peroxide (H 2 O 2 ) in CSE increases with the tar content of cigarettes and leads to progressive oxidative damage in BBB ECs TS is a major exogenous source of free radicals contained in both gaseous phase and tar, which can spawn sustained high levels of ROS (e.g., H 2 O 2 ) that may directly affect the BBB integrity

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Strong household smells often come from a variety of sources

Cells and organoids exposed to WCSE treatment chronically showed improved survival, reorganization of mitochondrial networks, and persistent activation of antioxidant defense pathways through NRF2 stabilization

Many states offer nicotine replacement therapy and free counseling as part of settlement agreements between states and Big Tobacco