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These covariates reflected the risk of bias associated with study design (prospective cohorts versus others), representativeness of the study population, exposure measurement (measured at baseline only versus multiple times during follow-up), outcome assessment method (self-report versus medical records), degree of control for confounding, and potential for selection bias (based on percentage follow-up for longitudinal study designs and percentages of cases and controls for which exposure data could be ascertained for casecontrol designs)

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Over the four years to 2020, the assumed weight decreased by 0.025 grams annually when calculating RYO excise in September of each year, in addition to the 12.5% annual excise increases

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