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Compared with sustainers, reducers and quitters were more likely to be older, have more comorbidities, and have a severe exacerbation history, but they were less frequent drinkers, had higher physical activity levels, and had a lower smoking pack-years at Exam 1 (Table 1)

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Or rarely

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As another indicator of FDAs intentions, the agencys guidance on nonclinical testing of inhaled nicotine drug products provides some insight into the requirements for sponsors seeking to market ENDS as drugs: toxicology testing and submission of information on components of the product, inhalation studies, assessment of product impurities, etc