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Higher doses (above 2mg/day) have not demonstrated proportional efficacy gains in published models and may increase copper ion toxicity risk

Others fail because they relax the wrong muscle or raise stomach pressure

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Treatment further enhanced DC maturation, boosted CD8 T-cell infiltration, reduced Treg accumulation, and elevated intratumoral IFN- and TNF- levels, demonstrating profound tumor immune microenvironment (TIME) remodeling and durable antitumor immunity