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Studies have consistently demonstrated a dose-response relationship between the quantity of cigarettes currently smoked and the risk of premature mortality in older adults [14]

Smoking can alter the activity of these enzymes, potentially leading to impaired detoxification processes

We know that nicotine itself acts on the opioid (and possibly cannabinoid) receptors, as well as the nicotinic receptors themselves

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Among them, the detailed smoking history of 700 IBD patients was available