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Next, glutaminases (GLSs), including glutaminase 1 (GLS1), glutaminase 2 (GLS2) and GAC (a splicing isoform of GLS1), convert Gln to glutamate (Glu) in the mitochondria, releasing ammonium ions ( Figure 1 ) (14)

This cytokine plays a dual role in MS and cuprizone models ( Glial responses mirrored the regional vulnerability seen in myelin dynamics, indicating distinct susceptibility to CPZ-induced CNS damage

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