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Nicotine, Stress, and Sleep Nicotine use may temporarily relieve stress, but it also increases heart rate, blood pressure, and cortisol levels , which are associated with heightened physiological arousal

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Physical addiction is a compulsive urge to use addictive substances despite physical complications and symptoms they cause

Grade 1: SJS mucosal erosions and epidermal detachment less than 10% Grade 2: Overlap SJS/TEN epidermal detachment between 10% and 30% Grade 3: TEN epidermal detachment more than 30% Protocols have been developed for SJS and TEN ( Table 18.3 )