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Past major depression and smoking cessation outcome: a systematic review and meta-analysis update

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Using nicotine flux as a regulatory target, all of the factors that influence it (e.g., device power, liquid nicotine concentration, user behavior) can be accounted for, and conditions that produce a flux that is too low (i.e., ineffective nicotine delivery) or too high (e.g., exceeding the flux of a combustible cigarette) can be made unavailable to consumers

Failure to promptly and adequately correct all violations and ensure compliance with all applicable laws and regulations may lead to enforcement actions, including civil money penalties (CMPs) or no-tobacco-sale orders (NTSOs)