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Despite being the only known product that if used as directed on the label is known to cause disease and death, tobacco is still sold in many locations and continues to contribute to considerable death and disability

Meanwhile, challenges like cross-border tobacco smuggling persist globally, influenced by the varied tobacco taxation impact across regions, while there is a growing focus on sustainable tobacco farming for tobacco leaf sourcing

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Multicollinearity among independent variables was assessed using the variance inflation factor (VIF)

Duration and Frequency Modifications Starting with shorter usage periods and reduced frequency helps assess individual tolerance and healing compatibility before returning to normal patterns