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Research has shown that compared with smokers smoking from branded packs, smokers who were smoking from standard packs were more likely to perceive their tobacco as being lower in quality, tended to be lower in satisfaction, and were more likely to think about and prioritise quitting

This leads to air trapping, hyperinflation of the lungs, and severe shortness of breath

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This applies when it is difficult to determine which substances are contributing to the disorders, often because users may not be aware of all the substances they are consuming

The addition of methyl groups to DNA reduces its accessibility to transcription factors, thus repressing gene transcription (Moore et al