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A Cochrane Living Systematic Review reports high-certainty evidence that nicotine e-cigarettes lead to higher quit rates than NRT, with a risk ratio of 1.55 , corresponding to three to six additional quitters per 100 users (Source: The 12-Week Tapering Model: How Reduction Actually Works Once smoking behavior is stabilized, effective protocols introduce a structured 12-week taper that alternates between two variables: Nicotine concentration reduction (typically in 2025% steps) Time-based use restriction , such as eliminating morning use first, then restricting vaping before work hours, and eventually limiting all use to short evening windows A pharmacist-led case report demonstrated that this alternating strategy enabled participants to reach complete nicotine abstinence by week 12 , without relapse (Source: A pilot study comparing cessation methods found that participants following a vape-taper protocol combined with behavioral support achieved a 75% nicotine-free rate at six months , outperforming both NRT and self-guided cessation approaches (Source: Addressing Compensatory Puffing: An Important Safety Consideration One important physiological challenge identified in recent trials is compensatory puffing

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