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We found that, even after factoring in the heterogeneity between studies and other sources of uncertainty, smoking has a strong-to-very-strong association with a range of health outcomes and confirmed that smoking is irrefutably highly harmful to human health

Academic Pediatrics

Nicotine is actually a poison, one that will cause an immediate reaction in your body, including: Increased blood pressure Stimulated heart Raised blood fat levels Constricted blood vessels Ironically, the purity of e-cigarette vapor means you are getting a much higher dose of nicotine with each vape

For a broader reference, see Wikipedia

Caffeine intake can influence the severity of tobacco withdrawal symptoms