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However, a more recent study has described impaired endothelial function even after a single nicotine-free ENDS session that was also accompanied by increased inflammatory mediators (i.e., serum CRP, plasma HMGB1) and oxidative stress [117]

[12] Appellate Body Report, Australia Certain Measures Concerning Trademarks, Geographical Indications and Other Plain Packaging Requirements Applicable to Tobacco Products and Packaging , WT/DS435/AB/R and WT/DS441/AB/R, para 6.389 (9 th June, 2020) (hereafter, Appellate Body Report, Australia Tobacco Plain Packaging )

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