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Finally, smokers with a higher than zero HSI were less likely to choose single cigarettes compared with those with an HSI=0 (OR=0.43)

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There's an additional JAMES BOND element ( 111A: Secret agent first introduced in 1953 ), with MARTINI ( 33D: Favorite drink of 111-Across ), and a bunch of circled double-"O" squares that, when connected, form the numeral "7" (thus making a "7" composed of DOUBLE "O" s or

This is a significant finding, as TRPA1 is activated by a multitude of both environmental irritants and endogenous mediators

A technology that more people use every year is, so far, almost entirely the product of two countries