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Given each SNP is allocated randomly at the time of conception, the MR results should be unconfounded by other factors for clozapine concentration, and therefore they can be thought of as approximately analogous to a series of natural randomized trials evaluating the effect of substance use on the concentration of clozapine

Grimmer G, Schneider D, Nanjack KW, Deltbarn G, & Jacob J (1995) Intercept-reactant method for the determination of aromatic amines in mainstream tobacco smoke

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Unlike cigars, pipe tobacco doesnt need a humid environment, so no humidor, but should be protected from excess air and moisture to avoid mold and flavor deterioration