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This is because CO displaces O 2 from hemoglobin forming carboxyhemoglobin (CO affinity for hemoglobin is 200 times that of O 2 ) and shifting the oxygen dissociation curve to the left, thereby causing hypoxia and impairment of cellular respiration [76]

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They are also leery of using the techniques that the tobacco industry promotes to reduce consumption, such as electronic cigarettes: there is no evidence that e-cigarettes are beneficial, and some scientific research says that they are actively harmful