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The urine biomarkers for adult smokers who used NSPS for five days and those who didnt smoke were almost at par, with the NSPS group reporting an aggregate mean reduction of 99.6% relative to the reduction associated with five days of abstention, found the study titled, Changes in Biomarkers of Exposure Associated with Switching for 5 Days from Combusted Cigarettes to Nicotine Salt Pod System

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Neuropsychopharmacology 27 , 727743 (2002)

In a The authors also note that consuming one bottle of wine per week has an association with an increased risk of alcohol-related cancers in women that is similar to the increase in risk associated with smoking 10 cigarettes per week

We recommend testing a small amount before scaling up to larger size formulations