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That year, PBATS estimated that approximately 33 percent of Major Leaguers used smokeless tobacco a figure thats down from 50 percent from two decades earlier, but still about five times higher than the rate of use among American men overall, which recently has been around 6 percent

In the subsequent sections, we explore recent advancements and challenges in biomass conversion, life cycle assessment, valorization of tobacco residues, microbial compatibility, agronomic and genetic optimization, sustainable land use, techno-economic feasibility, and supportive policy measures for the development of low-carbon tobacco-based biofuels ( Figure 1 )