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By the end of the 1920s, scientists already knew that tobacco smoke contained a small encyclopedia's worth of risky chemical compounds: carbon monoxide and hydrogen cyanide, hydrogen sulfide and formaldehyde, ammonia and pyridine (a component in industrial solvents)

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(2) natural tobacco blends with either a topping or a non-tobacco amendment such as deertongue

An FDA review of tobacco products scheduled for October is widely considered a move to address e-cigarette use