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Despite the obvious biologic plausibility, the lack of consistent epidemiological evidence might be due to methodological issues including lack of cohort follow-up time into older adulthood (when lung cancer usually becomes clinically manifest), small sample sizes, selection and recall biases, and lack of adjustment for tobacco use in the statistical modeling

Smoking is a leading cause of preventable diseases, including lung cancer, heart disease, stroke, and respiratory disorders

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Unsurprisingly the mice quickly learned to spend more time in the nicotine compartment

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