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Preclinical data demonstrates that PM-477 effectively inhibits Gardnerella biofilm growth and that it is not prone to resistance development, unlike metronidazole and clindamycin (93)

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Multivariate logistic models showed that urbanization (adjusted odds ratio (AOR) = 1.2) and having a history of systemic disease, including rheumatic disease (AOR = 2.1), genital aphthous disease (AOR = 11.7), depression (AOR = 1.3), chronic headaches (AOR = 1.8), diabetes mellitus (AOR = 1.6), and epilepsy (AOR = 2), were independent predictors of RAS