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Notably, these inhibitors ameliorated established PAH phenotypes in preclinical models, with 10 mg/kg compound 38 showing superior efficacy and a clearer dose-response than benchmark inhibitor compound 29 in the SuHx model

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Making It Easier for Women To Quit Smoking "If we can confirm that estrogen drives nicotine seeking and consumption through olfactomedins, we can design drugs that might block that effect by targeting the altered pathways," Pauss said