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The chemicals found in cigarette smoke, such as nicotine and carbon monoxide, can greatly Bone, joint, and muscle problems According to the American Academy of Orthopedic Surgeons, smoking can harm the health of bones, joints, and muscles, resulting in poorer outcomes from orthopedic surgery

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In studies involving overweight and obese patients with type 2 diabetes who were on various oral diabetes medications, the combined therapy of naltrexone and bupropion frequently led to ADRs such as nausea, constipation, vomiting, and diarrhea (Wharton et al., 2021)

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