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Tobacco smoking reduces p53, a tumor suppressor gene that is considered the genome guardian. Suppression of T-cell responses by Nicotine and tar is associated with decreased surveillance for tumor cells] reported that heavy smokers accumulate excess iron in hepatocytes which induces fibrosis and favors the development of HCC

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Crucially, the authors emphasize that these findings should not be interpreted as an endorsement of E-cigarette use, since E-cigarettes still pose potential health risks and their long-term impact on reproductive health is not fully understood

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