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Only studies involving adults ( 18 years) were included to avoid the heterogeneity introduced by juvenile or atypical Parkinsonian syndromes, which may differ in aetiology, progression, and treatment response

Mitochondria as central hubs in synaptic modulation

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doi:10.1016/j.freeradbiomed.2023.04.024 Alehagen U, Aaseth J, Lindahl TL, Larsson A, Alexander J

The main goal of 3D cultures is to provide cells with a bulk ECM with properties that guide cells to develop or sustain a desired phenotype and, implicitly, to rely upon the cells themselves to create a local 3D microenvironment that mimics the in vivo microenvironment