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Comparatively, smoking a single tobacco cigarette causes acute bronchoconstriction, which has been attributed to an irritant effect of the smoke leading to cholinergically mediated reflex bronchospasm [25]

It is thought to be a cause of around 5,000 miscarriages a year, as well as more than 100 still births and more than 100 infant deaths

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James Hetfield himself obviously never wanted to put just any celebrity stamp on a cigar - and Jonathan Drew doesn't do it for celebrities who want to immortalise themselves in this way