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Symptoms of poisoning can occur within 15 minutes to an hour after ingestion or absorption

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These two MAPKs are known to be involved in MMP transcription by activating protein-1 (AP-1), a transcription factor predominantly resulting from the formation of a heterodimer between c-jun and c-Fos and mediating the regulation of several genes in response to various stimuli, including growth factors and cytokines 50

Patients should be aware that the lack of formal interaction data does not eliminate the need for caution and clinical vigilance when using both substances concurrently