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The air sacs can fill up with fluid or pus and lead to symptoms like a cough, fever, trouble breathing, and stabbing chest pain, the ALA says

They were this close

"Phenylpropanolamine and the Risk of Hemorrhagic Stroke." N Engl J Med 343 (2000): 1826

69 The study also showed that diabetics who smoked had lower levels of protective HDL cholesterol (which further confirms the cholesterol effect discussed earlier), and they also had a significantly increased amount of protein in their urine, a marker of early kidney damage

There I ascertained the most important fact that I now know concerning the advance of glaciers, he wrote later