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The pipeline is also used as a model for innovation, based on the belief that innovation begins with research ideas, then are progressively refined by passing through different stages of development

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In Maine, 17% of adults are smokers, and what's more, the incidence of smoking-related cancers is higher than the national average.[4]

For cardiovascular disease, smoking triggers endothelial dysfunction, platelet activation, and atherogenesis through oxidized LDL and effects on nitric oxide and adhesion molecules