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Furthermore, patients with WT p53 expressing lung cancers were observed to exhibit better responses to cisplatin-based therapies compared to patients with mutant p53 expressing lung cancers [206, 207]

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Immunohistochemical staining using a panel of markers specific to stratified squamous epitheliumincluding the basal cell marker CK5, the differentiation markers IVL and FLG, the adhesion molecule DSG, and the transmembrane mucin MUC1confirmed the epithelial phenotype of these models (Fig

[122] In 1890, James Buchanan Duke founded the American Tobacco Company (ATC) and put the machines into mass-productions, which led to a decline in chewing tobacco and pipe smoking use in the United States